Abstract Background Molecular mechanisms involved in the pathogenesis of severe Plasmodium falciparum malaria (SM). are not yet fully understood. Both endothelin-1 (ET-1) and C-type natriuretic peptide (CNP) are produced by vascular endothelium and act locally as paracrine regulators of vascular tone. ET-1 being a potent vasoconstrictor and CNP having strong vasorelaxant properties. https://www.roneverhart.com/SWW-x-SXSW-Cake-Something-Was-Wrong-2-8x3/