Abolishing the inhibitory signal of intracellular cAMP is a prerequisite for effector T (Teff) cell function. The regulation of cAMP within leukocytes critically depends on its degradation by cyclic nucleotide phosphodiesterases (PDEs). We have previously shown that PDE8A. a PDE isoform with 40-100-fold greater affinity for cAMP than PDE4. https://www.shopredoners.shop/product-category/high-rise-wide-leg/